Lepton gene5/19/2023 ![]() Common polymorphisms of LEP have been associated with obesity. It was concluded that the LEP gene in SO cattle was showed polymorphisme and potential for molecular selection in the breeding program through depth research. Epigenetic analyses reveal that histone modifications, but not DNA methylation, underlie exon-specific transcription of the Bdnf gene induced by leptin. Gene polymorphism of leptin (loci rs7799039) and leptin receptor (loci rs1137101) are correlated with Growth hormone deficiency susceptibility. Background: Rare mutations in the leptin (LEP) gene cause severe obesity. Two type of mutation were detected in the LEP gene of SO cattle and consisted of transversions (44%) and transitions (56%). Normally, the bodys fat cells release leptin in proportion to their size. This SNP was changed the amino acid from Glycine (GGG) to Arginine (AGG). This gene provides instructions for making a hormone called leptin, which is involved in the regulation of body weight. The SNP of g.3468G/A as the novel SNP in LEP gene of SO cattle that not reported in other breeds of cattle. Total of 16 SNPs in LEP gene of SO cattle had moderate PIC value (0.25<0,50) and consisted of twelve SNPs in intron 2 and four SNPs in exon 3. The polymorphic informative content (PIC) value was reached from 0.06 (low) to 0.37 (moderate). To Lepton users around the world in more than 130 countries: We hope you all stay safe, healthy, and strong as we get through the COVID-19 pandemic. Along 2025 bp of LEP gene sequence was analyzed in this study and consisted of intron 2 (1002 bp) and exon 3 (1023 bp). Lepton is designed to make complex and beautiful particle effects possible, and even easy from Python programs. Research showed that total of 16 SNPs were detected in the LEP gene. increases expression of genes involved in cell cycle regulation such as CCND1. A total of 31 animals were used in this study for analyses. This study was carried out to identify single nucleotide polymorphisms (SNPs) in the LEP gene of Sumba Ongole (Bos indicus) cows using sequencing method. There is a single leptin gene (LEP) in humans one of its major functions is nutrient regulation as part of a signaling pathway that inhibits food intake. The bovine Leptin (LEP) gene was widely used as a candidate gene for molecular selection to improve productivity traits of cattle.
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